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Lilly says its obesity drugs helped patients lose weight in clinical trials

By Thomson Reuters Nov 14, 2026 | 11:03 AM

Nov 14 (Reuters) – Eli Lilly & Co on Saturday released some new data from several clinical trials of its ​obesity drugs for the ObesityWeek 2026 ‌medical conference, but it has not yet released the full results.

In the Phase 2 trial of EloraTZP, an investigational combination of eloralintide and ‌tirzepatide:

• ​Overweight or obese adults ⁠with type 2 diabetes ⁠who received EloraTZP had weight loss of up to an average of 23.3% at 48 weeks, Lilly said. It ​said up to 60% of participants on the drug no longer met ⁠the BMI criteria for ⁠obesity at 48 weeks.

• EloraTZP ​also lowered A1C by up to an ​average of 2.9%, with up to ‌77% of participants achieving normal blood sugar levels.

In Lilly’s Phase 3 SURMOUNT-ADOLESCENTS trials, which tested the drugmaker’s blockbuster obesity medicine ⁠Zepbound in children between the ages 12 and 18 years:

• Zepbound reduced BMI by an ⁠average of ‌21.4% at 72 weeks in ⁠adolescents with obesity, with more ​than ‌half no longer meeting the ​BMI criteria ⁠for obesity at 72 weeks.

• Participants also reported improvements in weight-related quality of life, including physical comfort and body esteem, Lilly said.

(Reporting by Michael Erman; Editing by ​Chizu Nomiyama)