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Report: 49ers DE Nick Bosa (calf) out multiple weeks

By Thomson Reuters Sep 25, 2026 | 11:24 AM

By Field Level Media

Sep 25 (Field Level Media) – San Francisco 49ers pass rusher ​Nick Bosa will be ‌sidelined for a “few weeks” with a calf injury, ESPN reported on Friday.

The five-time Pro Bowler ‌sustained ​the injury ⁠during practice Thursday ⁠and could land on injured reserve, per the report.

Bosa is not expected to play ​on Sunday when the 49ers (2-0) host the Arizona ⁠Cardinals (1-1) in Santa ⁠Clara, Calif.

Bosa, 28, ​played a total of 70 ​snaps in the first two ‌games while coming back from a torn right ACL sustained in Week 3 ⁠last season. He has recorded seven tackles (two for loss) with one quarterback ⁠hit.

Bosa ‌has recorded 64.5 ⁠sacks, 13 forced fumbles, ​169 ‌QB hits and ​285 tackles ⁠in 87 games (85 starts) since being drafted with the No. 2 overall pick by San Francisco in 2019.

(–Field ​Level Media)