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Vertex raises annual revenue forecast on cystic fibrosis drugs strength

By Thomson Reuters Aug 3, 2026 | 3:05 PM

Aug 3 (Reuters) – Vertex Pharmaceuticals on Monday raised the upper end of its annual revenue forecast, banking on robust demand for its cystic fibrosis ​treatments.

The company expects its annual revenue to ‌be between $13.1 billion and $13.2 billion, compared with $12.95 billion to $13.1 billion previously. Analysts on average expect 2026 revenue of $13.07 billion, according to data compiled by LSEG.

Vertex said its annual outlook excludes the ‌pending ​Crinetics acquisition and that an ⁠updated forecast will be ⁠provided after the deal closes, which is expected in the third quarter.

Here are more details:

• Vertex’s $10 billion acquisition of Crinetics expands its reach beyond cystic ​fibrosis, adding endocrine disorders to a diversification strategy that already includes povetacicept in kidney, Casgevy in sickle ⁠cell and Journavx in pain, ⁠analysts had said.

• The company’s new cystic ​fibrosis drug, once-daily triple combination therapy Alyftrek, brought in ​sales of $573.6 million during the second quarter, compared ‌with $156.8 million a year ago.

• The company’s older cystic fibrosis drug, combination therapy Trikafta, posted quarterly sales of $2.50 billion, missing estimates of $2.65 billion.

• Cystic fibrosis is a ⁠rare and progressive genetic disorder caused by the absence of a protein regulating salt and water transport in and out ⁠of cells, ‌leading to severe respiratory and digestive ⁠problems.

• Second-quarter total revenue rose 12% to $3.33 ​billion ‌from a year ago, beating estimates of $3.23 ​billion. The ⁠growth was driven by the continued performance of cystic fibrosis therapies, the company said.

• Vertex reported quarterly profit of $4.73 per share on an adjusted basis, in line with estimates.

(Reporting by Sneha S K in Bengaluru; Editing ​by Shreya Biswas)