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Novartis misses quarterly sales, profit estimates as Entresto generics hit growth

By Thomson Reuters Apr 28, 2026 | 12:11 AM

April 28 (Reuters) – Swiss drugmaker Novartis reported first-quarter core operating profit and sales below market expectations on Tuesday, as generic competition for its top-selling ​heart drug Entresto weighed on results.

Shares of the ‌drugmaker declined 3% in premarket trading on Tuesday.

Quarterly group operating income, adjusted for special items, declined 12% to $4.9 billion, below average analyst expectations of about $5.1 billion cited by Visible Alpha.

Novartis is navigating ‌its ​largest patent expiry in the last ⁠two decades, including for ⁠Entresto, which made up 14% of its total net sales last year.

CFO Mukul Mehta said on a call with reporters that the results were in line with ​the company’s internal expectations.

“We do expect growth to return back to our P&L in second half of ⁠this year,” he said.

Entresto saw ⁠first-quarter sales drop 42% to $1.31 billion after ​its U.S. patents expired and competing generics were launched. Entresto ​faces patent expiries in Europe starting November.

Analysts were expecting ‌sales of $1.37 billion for the first quarter ended March 31, according to data compiled by Visible Alpha.

Blood disorder drug Promacta and leukemia treatment Tasigna also face ⁠competition from generics, increasing the pressure on Novartis to deliver sales growth from newer drugs.

Total net sales for the quarter came ⁠in at $13.11 ‌billion, compared with analysts’ expectations of $13.40 billion.

The ⁠Swiss group has said it expects its ​sales ‌to decline by $4 billion this year due ​to competition ⁠from generics for Entresto and the other two drugs.      The Basel-based company also confirmed its full-year forecast of a low single-digit percentage core operating income drop, excluding currency swings.

(Reporting by Marleen Kaesebier and Bhanvi SatijaEditing by Ludwig Burger ​and Louise Heavens)