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Drug developer City Therapeutics files for US IPO as biotech listings surge

By Thomson Reuters Sep 24, 2026 | 3:47 PM

Sept 24 (Reuters) – Drug developer City Therapeutics filed for a US initial public offering on Thursday, joining a rush of biotech ​firms lining up to tap the ‌fall IPO window.

Biotech has been one of the key themes of the IPO market this year amid renewed investor interest in the industry, although fall listings have ‌struggled ​to gain momentum as surging ⁠bond yields, a ⁠tightening rate environment and concerns around the AI trade weigh on risk appetite.

ADARx Pharmaceuticals, which is developing RNA-based drugs for rare diseases, is ​expected to go public in New York on Friday.

Drug developers Retension Pharmaceuticals, TRex Bio and Iambic ⁠Therapeutics earlier this month ⁠also unveiled their US IPO filings, ​a key step ahead of a potential roadshow launch.

Founded ​in 2023, City Therapeutics is advancing a ‌pipeline of RNA-based drugs for rare diseases. Its most advanced product candidate, CITY-FXI, is in an early-stage trial to treat thrombosis, which is the ⁠formation of harmful clots inside a blood vessel.

The Cambridge, Massachusetts-based company has raised roughly $238.8 million since inception ⁠from life sciences ‌investors, including ARCH Venture Partners, ⁠Fidelity Management & Research Company, Invus, and ​Viking ‌Global Investors.

City Therapeutics plans to sell ​new shares ⁠in the IPO.

Goldman Sachs, Jefferies, Stifel and Oppenheimer are the underwriters for the offering. The company will list on the Nasdaq under the symbol “CTY.”

(Reporting by Arasu Kannagi Basil in Bengaluru; Editing by ​Jonathan Ananda)