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U.S. court orders Guardant to pay $245 million in DNA sequencing patent dispute

By Thomson Reuters Aug 24, 2026 | 6:25 AM

Aug 24 (Reuters) – A U.S. court has ordered Guardant Health to pay more than $245.2 million to TwinStrand Biosciences and the University of Washington ​after finding that the company infringed patents covering ‌DNA sequencing technology, TwinStrand said on Monday.

Here are the details:

• The U.S. District Court for the District of Delaware entered final judgment on August 21, upholding a 2023 jury verdict ‌that ​found Guardant had willfully infringed two ⁠patents related to TwinStrand’s ⁠DNA sequencing technology.

• The court ordered Guardant to pay a 6% royalty on U.S. sales of 11 products and services found to infringe the patents ​until they expire in March 2033.

• The judgment includes $83.4 million in original damages, $19.5 million in supplemental damages, $119.4 ⁠million in accrued royalties, and $22.9 ⁠million in pre- and post-judgment interest.

• ​TwinStrand said the products and services covered by the ruling ​accounted for about 90% of Guardant’s revenue during ‌the infringement period.

• The products covered by the ruling include Guardant360 CDx, Guardant Reveal, the Shield cancer test and several other cancer testing and genomics services ⁠sold by Guardant.

• Guardant had sought to overturn the verdict or obtain a new trial, but the court rejected those ⁠efforts, TwinStrand ‌said.

• The judgment also upheld the validity ⁠of the patent claims at issue, ​TwinStrand said.

• ‌TwinStrand’s Duplex Sequencing technology is designed ​to detect ⁠rare genetic mutations with greater accuracy than conventional DNA sequencing methods.

• TwinStrand said its technology, developed at the University of Washington, is used in cancer research, diagnostics and drug development.

(Reporting by Kamal Choudhury in Bengaluru; Editing ​by Tasim Zahid)