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Moderna short-sellers stare at record one-day loss as shares surge on vaccine data

By Thomson Reuters Aug 19, 2026 | 10:18 AM

Aug 19 (Reuters) – Investors betting against shares of Moderna faced record one-day losses on Wednesday as the ​biotech company’s stock more than doubled ‌in value following upbeat data on its personalized mRNA cancer therapy.

At $159, short sellers were on pace for about $4.8 billion in mark-to-market ‌losses, ​according to data analytics ⁠firm ORTEX.

“With each shorted ⁠share now down almost $100, that is exactly the kind of pressure that can trigger a squeeze,” said Peter ​Hillerberg, co-founder of ORTEX.

“There is clearly a real catalyst behind a move ⁠this size, but ⁠with a short base this ​large, shorts scrambling to cover are adding ​fuel and can keep driving the price ‌higher.”

The company’s shares rallied to hit $163 before pulling back slightly to trade at $148.3.

Short interest in Moderna’s shares stood ⁠at 13.5% of its free-float as of Wednesday, making it one of the most-shorted large-cap ⁠stocks, ORTEX ‌estimates.

Moderna shares were set ⁠for a record one-day percentage ​gain ‌after its personalized mRNA cancer ​therapy, developed ⁠with Merck, reduced the risk of skin cancer recurrence and spread in a late-stage trial when combined with Keytruda.

(Reporting by Shashwat Chauhan in Bengaluru; Editing by ​Sriraj Kalluvila)