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Novo CEO faces investor grilling after outlook hike soured by pipeline concerns

By Thomson Reuters Aug 5, 2026 | 12:58 AM

By Stine Jacobsen and Maggie Fick

COPENHAGEN, Aug 5 (Reuters) – Novo Nordisk CEO Mike Doustdar faces investors and analysts on Wednesday under pressure to restore confidence in the drugmaker’s longer-term ​growth prospects after an upgraded 2026 outlook failed to ‌reassure markets.

The Danish drugmaker raised its full-year profit and sales outlook late on Tuesday but disappointed investors who focused instead on a narrow sales miss for its new Wegovy pill and a trial setback for its next-generation obesity ‌drug ​CagriSema.

Its U.S.-listed ADRs slipped 6%, indicating a ⁠likely fall when the ⁠stock opens in Copenhagen on Wednesday. The shares, which had been rallying since March, are down 5% this year.

NOVO NEEDS A ‘STRONG PIPELINE’ AHEAD OF PATENT EXPIRIES

With the quarterly numbers out, attention ​is shifting from financial performance this year to whether Doustdar can convince investors Novo has a credible growth story beyond ⁠semaglutide.

“They need to have a strong pipeline ⁠to withstand the pressure when semaglutide hits the ​patent gap,” said Morten Gregersen, chief portfolio manager at Danish Novo shareholder ​Formuepleje. “There is another disappointment from Cagrisema, and it probably ‌underlines the biggest strategic problem for Novo.”

Investors will be looking for details on a call with management at 1100 GMT on U.S. sales of oral Wegovy, the implications of the latest CagriSema data, ⁠broader R&D priorities and whether recent pipeline setbacks increase the likelihood of acquisitions or licensing deals.

The CagriSema results marked the latest setback following ⁠earlier trial disappointments, adding ‌to investor concerns over Novo’s next-generation obesity ⁠medicines as well as its ability to develop ​its portfolio ‌beyond obesity and diabetes.

“This puts the spotlight on ​Novo Nordisk’s ⁠pipeline and its robustness,” AL Sydbank said in a note to clients, adding that while Novo’s earnings should have prompted a sigh of relief from investors, the data and impairment charges had dented sentiment.

(Reporting by Stine Jacobsen, Maggie Fick, Bhanvi Satija; Editing by Adam Jourdan ​and Rashmi Aich)