×

AstraZeneca shares slide 7% after reports of Bristol Myers talks

By Thomson Reuters Aug 3, 2026 | 2:20 AM

By Maggie Fick

LONDON, Aug 3 (Reuters) – AstraZeneca’s shares fell sharply on Monday as analysts and investors questioned the logic of a possible tie-up with Bristol Myers Squibb ​after reports they held preliminary talks about forming ‌one of the world’s biggest drugmakers.

Shares in AstraZeneca were down 6.7% at 0722 GMT, the biggest drop on the FTSE 100 index, as investors and analysts said Britain’s biggest drugmaker had little obvious need for a ‌transformative ​acquisition despite potential financial benefits.

A person ⁠familiar with the matter told ⁠Reuters that AstraZeneca and Bristol had held talks, confirming an earlier Financial Times report. On Friday, the two had a combined market capitalisation of nearly $400 billion, with AstraZeneca valued ​at $264.11 billion and Bristol Myers at $133.41 billion.

“A combination with Bristol does not make strategic or financial sense,” said Markus ⁠Manns, portfolio manager at Union Investment, ⁠an AstraZeneca shareholder.

“Many past mega-mergers have destroyed value ​and there is no apparent need for Astra to do ​it,” he added.

While AstraZeneca this year completed a direct ‌listing on the New York Stock Exchange, underscoring its focus on its biggest market and its aim of benefiting from higher U.S. valuations, a Bristol Myers deal would effectively mean a ⁠British company buying a major U.S. pharmaceutical champion.

Manns said AstraZeneca CEO Pascal Soriot had, in his 14 years at the helm, consistently ⁠prioritised research and ‌development over cost-cutting. “A merger would deeply disrupt a ⁠well-run company with a full pipeline,” he ​warned.

Jefferies ‌analysts said in a note they were puzzled ​by the ⁠reports of talks given AstraZeneca has a strong “growth and innovation profile”. “If there is one company that doesn’t need financial engineering, it’s AstraZeneca,” they wrote.

(Reporting by Maggie Fick in London, Prerna Bedi and Pushkala Aripaka in Bengaluru; Editing by Nivedita Bhattacharjee, Janane Venkatraman ​and Alexander Smith)