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US drug overdose deaths dropped for third straight year in 2025, CDC data shows

By Thomson Reuters May 13, 2026 | 9:06 AM

May 13 (Reuters) – Drug overdose deaths in the United States fell nearly 14% in 2025, ​federal estimates showed on ‌Wednesday, marking a third consecutive year of declines.

Here are some details:

• Nearly 69,973 people died from drug overdose in ‌the ​U.S. in 2025, ⁠compared with 81,313 ⁠deaths estimated a year earlier, according to provisional data from the U.S. Centers for Disease Control ​and Prevention.

• The wide availability of a medication called naloxone, ⁠a potent overdose ⁠antidote, has significantly contributed ​to the drop, according to experts.

• ​Deaths involving opioids fell to an ‌estimated 44,564 in 2025 from 55,296 a year earlier, the CDC estimates showed.

• Synthetic opioids, ⁠including Fentanyl, are the single largest contributor to overdose deaths in the country.

• While ⁠most ‌states across the nation ⁠showed declines in overdose ​deaths, ‌New Mexico, Arizona and ​Colorado had ⁠increases of 10% or more compared to the same period in 2024, the report said.

(Reporting by Mariam Sunny in Bengaluru; Editing by ​Shailesh Kuber)