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Eli Lilly extends partnership with Insilico Medicine for AI-powered drug discovery

By Thomson Reuters Mar 29, 2026 | 7:03 PM

March 29 (Reuters) – Insilico Medicine said on Sunday it is partnering with Eli Lilly in ​a deal worth up to $2.75 ‌billion, expanding an existing collaboration on AI-powered drug discovery.

Lilly will use Insilico’s AI engine and receive an exclusive ‌worldwide ​license for the ⁠development, manufacturing, and commercialization ⁠of certain oral treatments currently in preclinical development.

Under the terms of the agreement, Insilico is eligible ​to receive a $115 million upfront payment, followed by development, ⁠regulatory, and commercial ⁠milestones that could bring the ​total deal value to approximately $2.75 billion, ​plus tiered royalties on future ‌sales.

“By deploying AI technologies that scale from biomarkers to life models, world models of human and ⁠animal life, we can identify multi-purpose targets driving multiple diseases at the same ⁠time,” said ‌Alex Zhavoronkov, founder and ⁠CEO of Insilico Medicine.

Lilly ​and ‌Insilico had signed a ​research collaboration ⁠in November, broadening a partnership that began with an AI-based software licensing agreement in 2023.

(Reporting by Christy Santhosh in Bengaluru; Editing by ​Tasim Zahid)