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More than a third of patients on Wegovy pill are new to GLP-1 drugs, study finds

By Thomson Reuters Feb 11, 2026 | 12:12 PM

By Robin Respaut

SAN FRANCISCO, Feb 11 (Reuters) – Among early users of Novo Nordisk’s new Wegovy weight-loss pill, 36% had no prior experience taking a GLP-1 medication, a new ​nationwide study from the health data firm Truveta found.

Of patients ‌who started a new pill prescription, 21.1% had previously taken the injectable version of Wegovy and 15.8% switched from Eli Lilly’s Zepbound, another injectable GLP-1 medicine, according to Truveta data.

The Wegovy pill is the first oral GLP-1 drug ‌approved ​to treat chronic weight management, creating a ⁠new option for patients and ⁠providers who might not want an injectable medicine.

The fast uptake among those without prior experience with GLP-1 drugs shows that the oral medication is reaching new patients rather than just ​taking market share from the injectables, something analysts and investors have been eager to gauge.

Truveta reviewed health records from 8,762 U.S. ⁠patients with evidence of a prescription ⁠written or filled for the new Wegovy pill, which ​won U.S. approval on December 22.

During the first six weeks that ​the pill has been available to patients, Truveta found ‌that 73.3% of those with prescriptions are female, 72.8% are white and 71.6% live in urban areas. The group also skewed older as 34% were ages 45 to 59 years, and 37.8% were ⁠age 60 or older.

The data offers an early glimpse of patients on oral Wegovy, which may change over time.

For example, more patients currently taking ⁠injectable GLP-1 medicines ‌may switch to the pill in the coming ⁠weeks, after they finish their current supply, Truveta ​noted.

A ‌rival oral weight-loss medication from Lilly is expected ​to be ⁠approved in April.

Novo is selling lower doses of its daily pill in the United States for $149 per month for self-paying patients, rising to $199 in April.

In January, Truveta reported that prescriptions for GLP-1 therapies now account for over 7% of all prescriptions nationwide.

(Reporting by Robin RespautEditing ​by Bill Berkrot)