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Immunome’s experimental drug meets main goal in late-stage study

By Thomson Reuters Dec 15, 2025 | 6:20 AM

Dec 15 (Reuters) – Immunome said on Monday its experimental drug ‍met the main goal in a late-stage study for patients with a rare type ‌of tumor.

The oral ‌drug, varegacestat, is being tested in patients with desmoid tumors, also known as ​aggressive fibromatosis or desmoid-type fibromatosis, that ‍are aggressive ​non-metastatic soft tissue ​tumors that are prone ‍to recurrence.

The trial showed varegacestat significantly improved progression-free survival compared with placebo, cutting ‍the risk of disease progression or death by 84%.

Immunome ‍plans ‍to file for ​U.S. approval ​in ⁠the second quarter ‌of 2026.

Shares of cancer drug developer were up 30% in premarket trading.

(Reporting by Siddhi Mahatole in ⁠Bengaluru)