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Altimmune’s weight-loss drug meets main goal in fatty liver disease trial

By Thomson Reuters Jun 26, 2025 | 6:43 AM

(Reuters) – Altimmune said on Thursday its experimental obesity drug met the main goal of a mid-stage trial studying it as a potential treatment for a fatty liver disease.

The drug, pemvidutide, showed a subsiding of metabolic dysfunction-associated steatohepatitis (MASH), or non-alcoholic steatohepatitis (NASH), without a worsening of liver scarring in up to 59.1% of participants in the 212-patient trial.

A weight loss of up to 6.2% was also seen in the trial.

Despite the positive results, shares were down 56% premarket.

Pemvidutide is being studied separately as an obesity treatment.

(Reporting by Puyaan Singh in Bengaluru; Editing by Devika Syamnath and Sriraj Kalluvila)